2nd SYMPOSIUM: CONNECTION BETWEEN PHYSICS AND METABOLISM IN BRAIN FUNCTIONS

ICM Institute for Brain and Spinal Cord

47 Boulevard de l'Hôpital, 75013, Paris, IDF, France

Dr Fanny Mochel & Dr Angeles García-Cazorla

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Fanny Mochel is a professor of genetics at Sorbonne University. Prof. Mochel leads a national reference center for neurometabolic diseases in adults as well as a national reference center for leukodystrophies in adults. She is also the co-team leader of the MIND team (“Metabolism, Immunity and NeuroDegeneration”) at the Paris Brain Institute of La Pitié-Salpêtrière University Hospital in Paris. From 2018 to 2024, she served as chair of the Adult Metabolic Physicians group of the Society for the Study of Inborn Errors of Metabolism (SSIEM) and she is co-chair of the French society for inborn of errors of metabolism in adults since 2014. Her research has focused on the characterization and treatment of brain energy deficiencies in neurometabolic and neurodegenerative diseases. Her major areas of expertise are the identification of neurometabolic biomarkers in vitro (metabolomics) and in vivo (metabolic imaging) as well as therapeutic approaches targeting the Krebs cycle.Prof. Ángeles García-Cazorla (University of Barcelona; Sant Joan de Déu Hospital) is a paediatric neurologist with expertise in neurometabolic and neurodevelopmental disorders. She studies how metabolic imbalances affect brain function, particularly in children with rare neurological disorders. Her work integrates clinical practice and research to improve diagnosis and treatment strategies.Together they have a long history of exploring the complex relationship between metabolism and brain function. Their work in neurometabolic disorders has highlighted the need for a broader, interdisciplinary approach that incorporates fundamental physical principles.On July 5, 2024, Prof. Fanny Mochel and Prof. Angela Garcia-Cazorla (Barcelona University) organized an international symposium that led to a groundbreaking encounter between physicists and neurobiologists to address the central role of physics and metabolism in brain functions and diseases. Cellular mechanics, energy flow, neurotransmission and even sensory processing all operate according to mechanistic principles that physics can help elucidate.This second symposium in Paris (November 7, 2025) continues its mission to advance our understanding of how physical principles shape brain function and disease by pushing the boundaries of modern neuroscience and neurometabolism, bringing together experts in physics, chemistry, neurobiology and philosophy. It aims to foster interdisciplinary collaboration, generate new hypotheses and develop innovative approaches to the study and treatment of neurometabolic diseases.