What is Limb-Girdle Muscular Dystrophy, type 2D / R3?Limb-Girdle Muscular Dystrophy (LGMD) is a group of rare
muscular disorders that generally present with weakness in the
hips and shoulder muscles. LGMD2D / R3 is an autosomal
recessive disease caused by alpha-sarcoglycan gene mutations
that lead to a functional alpha-sarcoglycan protein deficiency.
LGMD2D is one of the most severe forms of limb-girdle
muscular dystrophies.Currently, no treatments are available for LGMD2D patients to help slow or stop
disease progression.The LGMD2D Foundation is a registered 501(c)3 non-profit foundation built for families
living with LGMD2D - both patients and caregivers - by families with the same diagnosis.
Our mission is to expedite the development of treatments or a cure for Limb-Girdle Muscular
Dystrophy, type 2D / R3 (LGMD2D).