SPRINGS is an EU-funded project focused on addressing the impact of climate change on waterborne diarrheal diseases. Diarrheal diseases are currently the third leading cause of death in children under 5 years of age globally. Compounded by global climate projections indicating increased precipitation, flooding, and drought, there is a looming threat to the progress made in reducing diarrheal disease burden. To inform and prioritise effective political responses, SPRINGS is building 4 case studies in Italy, Ghana, Romania, and Tanzania with contrasting vulnerabilities.